Compound, composition and method for the treatment of inflammatory and inflammatory-related disorders

Compound, composition and method for the treatment of inflammatory and inflammatory-related disorders

  • CN 1,451,041 B
  • Filed: 03/26/2001
  • Issued: 06/16/2010
  • Est. Priority Date: 03/24/2000
  • Status: Active Grant
First Claim
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1. prevent or treat the pharmaceutical composition of inflammation by stabilizing cell membrane, it is characterized in that described composition comprises a certain amount of purifying Yeast Nucleic Acid and pharmaceutically acceptable vehicle, carrier or thinner, the amount of described purifying Yeast Nucleic Acid is the symptom of amelioration of inflammation effectively, wherein said purifying Yeast Nucleic Acid is total yeast extract, derives from Candida utilis (Candidautilis) and purifying through the following steps:

  • Sodium chloride solution with 10-12% carries out the yeast rna extraction at 100-110 ℃

    ;

    RNA solution is separated from the yeast sedimentation thing;

    Be cooled to 0 ℃ and

    with hcl acidifying to pH 1-2, obtain RNA precipitation;

    With the alcohol rinsing, drying precipitated;

    AndCarry out following purification step and obtain the RNA extract;

    Precipitate water-soluble formation solution,This solution is adjusted to pH 8.0-8.2 by sodium hydroxide, places 1 hour at 37-40 ℃

    behind the adding trypsinase, and heating makes enzyme deactivation then,Filtering solution,RNA is by the refrigerative alcohol precipitation, andWith hcl acidifying to pH 1-2, and the precipitation of dry purifying.

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