Improved injectable dispersions of propofol

Improved injectable dispersions of propofol

  • CN 1,460,019 A
  • Filed: 06/14/2001
  • Published: 12/03/2003
  • Est. Priority Date: 06/16/2000
  • Status: Abandoned Application
First Claim
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1. a sterilization, the little matrix of injectable homogenize or the dispersion of microdroplet, little matrix or the about 50nm of microdroplet average diameter are to about 1000nm, comprise about 1% to about 7.5% propofol, about 1% to about 8% propofol solubility diluent, with about 0.67% to about 5% surface-stable amphiphilic reagent, be suspended in the aqueous medium of excipient of pharmaceutically acceptable water miscible hydroxyl of the antimicrobial that contains collaborative amount and tension adjustment amount, wherein propofol is about 0.25 to about 7.5 with the scope of the ratio of diluent, and the scope of propofol and the ratio of amphiphilic reagent is about 0.4 to about 1.5, and wherein the range of viscosities of dispersion is 1.1 to 8cps.

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