Vero cell fick-borne encephalitis inactivated vaccine

Vero cell fick-borne encephalitis inactivated vaccine

  • CN 1,513,553 B
  • Filed: 06/02/2003
  • Issued: 11/24/2010
  • Est. Priority Date: 06/02/2003
  • Status: Active Grant
First Claim
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1. the preparation method of a Vero cell deactivation Teck-borne Encephalitis Vaccine is characterised in that to comprise following step:

  • (1) cultivation is from the Vero cell of cell line cell;

    (2) in culture fluid, with fores encephalitis virus gloomy " opening " Strain P 9-3Vero cells infection, the viral liquid of virus of proliferation suspensions in the Vero cell that infects;

    (3) the viral liquid that obtains in results (2) step;

    (4) by slightly carrying, concentrate and the column chromatography step being removed residue culture and/or foreign protein in this virus liquid, purified virus suspension;

    (5) the viral liquid that deactivation obtains before or after (4) step;

    (6) with the purification inactivation of viruses liquid that obtains in (5) step, be mixed with vaccine with adjuvant.

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