Process for producing sulbactam valeryl oxygen methyl ester

Process for producing sulbactam valeryl oxygen methyl ester

  • CN 1,523,026 A
  • Filed: 02/22/2003
  • Published: 08/25/2004
  • Est. Priority Date: 02/22/2003
  • Status: Active Application
First Claim
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1. , a kind of production technique of Sulbactam pivalyl oxygen methyl esters is characterized in that:

  • The raw material of a, production Sulbactam pivalyl oxygen methyl esters adopts Sulbactam acid, Chloro methyl pivalate, dimethyl formyl and organic amine compound, and its proportioning (by weight) is;

    Sulbactam acid;

    Chloro methyl pivalate;

    the dimethyl formyl;

    organic amine compound=1;

    0.5~

    1;

    2~

    6;

    0.1~

    1.2;

    B, production process is;

    with the Sulbactam acid that takes by weighing, Chloro methyl pivalate, dimethyl formyl and organic amine compound are put into container and were carried out condensation reaction 12~

    40 hours, after treating that condensation reaction finishes, the water and the solvent orange 2 A that add 3~

    6 times of Sulbactam acid weight extract, divide water-yielding stratum, water layer extracts with the solvent orange 2 A of 1~

    3 times of Sulbactam acid weight, merge organic layer, water washing organic solvent layer with 1.5~

    2 times of Sulbactam acid weight, salt solution with 3~

    6 times of Sulbactam acid weight washs, add activated carbon decolorizing, filter, feeding is decompressed to residue and is sugar folding shape (emitting folding), the solvent B that adds 1.5~

    3 times of Sulbactam acid weight dissolves, lysate is cooled to below 20 ℃

    , after the crystallization 3 hours, filter, filter cake washs with solvent B, drain, get the off-white color crude product, the crude product that takes by weighing, the solvent C that adds 3~

    5 times of crude product weight, intensification makes its dissolving, is cooled to below 15 ℃

    crystallization, place more than 3 hours, filter, filter cake is drained with an amount of cold solvent C making beating washing, drying, the Sulbactam pivalyl oxygen methyl esters finished product of white or off-white color Cheng Jing.

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