Celecoxib compositions

Celecoxib compositions

CN
  • CN 1,537,531 A
  • Filed: 11/30/1999
  • Published: 10/20/2004
  • Est. Priority Date: 11/30/1998
  • Status: Abandoned Application
First Claim
Patent Images

1. pharmaceutical composition, comprise one or more dosage units that can oral release, each dosage unit comprise about 10mg in the plug of 1000mg former times the cloth granule with the dense mixture of one or more pharmaceutically acceptable excipient, produce plug cloth serum-concentration of interior former times and time relation during wherein single dosage unit orally give fasting patients with following at least feature:

  • (a) time that reaches 100ng/ml concentration after the administration is no more than about 0.5 hour;

    (b) reach Cmax (T after the administration Max) time be no more than about 3 hours;

    (c) keep the time of concentration more than 100ng/ml to be no less than about 12 hours;

    (d) half-life (T 1/2) time of finishing is no less than about 10 hours;

    With (e) Cmax (C Max) be not less than about 200ng/ml.

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