Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity

Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity

  • CN 1,555,411 A
  • Filed: 08/05/2002
  • Published: 12/15/2004
  • Est. Priority Date: 08/03/2001
  • Status: Active Application
First Claim
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1. one kind is passed through to express at least a coding β

  • (1;

         4)-nucleic acid of N-acetylamino glucotransferase III (GnTIII) and produce the engineering host cell of the Cytotoxic polypeptide of Fc-mediation with raising;

    wherein the described polypeptide that is produced by described host cell is selected from whole antibody molecule;

    antibody fragment;

    with the fusion rotein that comprises with zone of equal value, the Fc district of immunoglobulin (Ig), and wherein reach described GnTIII with respect to the scale of the ratio of the polypeptide that has five equilibrium complex body oligosaccharides in the Fc district to be enough to improve the described polypeptide that has five equilibrium heterozygosis oligosaccharides or galactosylation complex body oligosaccharides or its mixture in the Fc district.

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