Immunogenic peptide composition for the prevention and treatment of Alzheimer's disease

Immunogenic peptide composition for the prevention and treatment of Alzheimer's disease

  • CN 1,568,329 B
  • Filed: 04/02/2002
  • Issued: 07/17/2013
  • Est. Priority Date: 05/25/2001
  • Status: Active Grant
First Claim
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1. one kind is about 20-100 amino acid whose peptide based immunogens, and it is made up of following:

  • (i) a kind of helper T cell epitope of being formed by SEQ ID No;

    51;

    (ii) A β

    1-42The N-terminal fragment of peptide SEQ ID NO;

    65, described A β

    1-42Peptide N-terminal fragment is made up of 10-28 amino-acid residue, and wherein each fragment comprises A β

    1-42First amino-acid residue-aspartic acid of peptide, and described A β

    1-42The N-terminal fragment of peptide is selected from SEQ ID NOs;

    66,67,68 or 69;

    With (iii) a spacerarm of being made up of at least a amino acid is to isolate the immunogenic structure territory, and described spacerarm is Gly-Gly, ε

    -Lys or Methionin, or described spacerarm is for strengthening Th and A β

    1-42The flexible hinge that separates between the peptide N-terminal fragment, Wherein said helper T cell epitope is covalently bound to described A β

    by described spacerarm 1-42The C-terminal of peptide N-terminal fragment.

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