Cyclovirobuxinum D crystal, its mono-methanol crystal, and preparation and use thereof

Cyclovirobuxinum D crystal, its mono-methanol crystal, and preparation and use thereof

  • CN 1,594,355 B
  • Filed: 06/18/2004
  • Issued: 12/08/2010
  • Est. Priority Date: 06/18/2004
  • Status: Active Grant
First Claim
Patent Images

1. cyclovirobuxinum D one methanol crystallization body, its chemical formula is C 27H 50N 2O 2, belonging to oblique system, spacer P2 (1), unit cell dimension are about a=7.2538 (15) A, b=7.8851 (16) A, c=23.069 (5) A, α



  • =90 °

    , β

    =94.30 °

    , It is the copper palladium through 105 ℃

    of dried powder at x ray generator X-ray diffractometer on carry out powdery diffractometry and measure, be 15.317 ±

    2%, 13.034 ±

    2%, 14.526 ±

    2%, 20.930 ±

    2%, 16.280 ±

    2% diffraction peak to be arranged in 2 θ

    diffraction angle, peak intensity is arranged in order according to said sequence and reduces, It adopts TLC stratographic detection system to be;

    thin layer plate adopts silica gel g thin-layer plate, developping agent to adopt chloroform;

    hexane;

    methyl alcohol;

    ammoniacal liquor=2.5;

    4;

    1;

    0.1 solvent, developer adopt rare bismuth potassium iodide test solution, point sample amount detecting between 100~

    250 μ

    g, principal spot on its thin layer plate and can not removing does not have the impurity spot to occur between the impurity spot, the number of the impurity spot of product is less than 3, and the number of the impurity spot of its other product of medicine reference substance level is 1.

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