Gram positive bacteria preparations for the treatment of diseases comprising an immune dysregulation

Gram positive bacteria preparations for the treatment of diseases comprising an immune dysregulation

  • CN 1,602,199 B
  • Filed: 12/11/2002
  • Issued: 04/04/2012
  • Est. Priority Date: 12/11/2001
  • Status: Active Grant
First Claim
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1. the compositions that contains Mycobacterium bovis BCG (the Mycobacterium bovis BCG) cell of the deactivation of non-degeneration can induce modulation to autoantigen or immunogenic immunne response at a kind of said medicine of purposes that is used for preventing and/or treating the medicine that is selected from cancer, autoimmune disease or hypersensitive disease of preparation;

  • Wherein said compositions does not comprise Mycobacterium bovis BCG and any desiccant of any work;

    And said compositions prepares through a kind of degree of depth freeze drying process, and said method comprises following steps at least;

    The culture of the Mycobacterium bovis BCG cell that-collection is lived,-freezing said Mycobacterium bovis BCG cell in water or in the aqueous solution of salt,-with its deactivation, the time of processing is enough to remove at least 98.5% moisture through in freeze dryer, said refrigerated Mycobacterium bovis BCG cell being carried out dried, andThe Mycobacterium bovis BCG cell of the described degree of depth lyophilizing deactivation of-collection.

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