Covalently linked oligonucleotide minor grove binder conjugates

Covalently linked oligonucleotide minor grove binder conjugates

  • CN 1,644,585 A
  • Filed: 04/03/1996
  • Published: 07/27/2005
  • Est. Priority Date: 04/03/1995
  • Status: Abandoned Application
First Claim
Patent Images

1. the binding substances of oligonucleotide and minor groove binding, comprise the oligonucleotide that contains a plurality of nucleotide units, one 3 '"'"' end and one 5 '"'"' end and basicly combine base with the covalently bound ditch of at least one described Nucleotide by being connected, it is described that to connect base covalently bound in conjunction with base and oligonucleotide with ditch by being no more than 15 atom, wherein said ditch is that molecular weight is the ditch bonded molecular radical of about 150-2000 dalton with non-embedded mode and double-stranded DNA, RNA or heterozygote in conjunction with base, and its association constant is greater than 10 3M -1

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×