A method for identification, isolation and production of antigens to a specific pathogen

A method for identification, isolation and production of antigens to a specific pathogen

  • CN 1,649,894 A
  • Filed: 01/21/2002
  • Published: 08/03/2005
  • Est. Priority Date: 01/26/2001
  • Status: Active Application
First Claim
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1. identify, separate and prepare the method for hyper-immuneserum reactive antigen, this antigen is derived from specific pathogen, tumour, tends to cause allergen or the tissue or the host of autoimmune response, this antigen is applicable to the vaccine of animal or human'"'"'s class of given kind, this method be characterized as following steps:

  • -provide from the blood plasma storehouse of this given animal or from the antibody preparations of human plasma storehouse or individual serum, wherein contain at described specific pathogen, tumour or tend to cause allergen or the tissue or host'"'"'s the antibody of autoimmune response-at least a above-mentioned specific pathogen, tumour are provided or tend to cause the allergen of autoimmune response or tissue or host'"'"'s expression library,-screen above-mentioned at least a expression library with above-mentioned antibody preparations,-identify in this screening the antigen that combines with antibody in this antibody preparations,The antigen that-use is identified from the individual antibody preparations screening of the individual serum of individuality, this individuality contain at specific pathogen, tumour or tend to cause the allergen of autoimmune response or tissue or host'"'"'s antibody,-identify the described antigenic hyper-immuneserum reactive antigen part that has identified, and this hyper-immuneserum reactive antigen is in conjunction with the relevant portion that is derived from the individual antibody preparations of this individuality serum;

    AndThe described hyper-immuneserum reactive antigen of-optional separation, and produce described hyper-immuneserum reactive antigen by chemistry or recombination method.

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