Method and application of preparing oral powder of insulin through microcapsule technique

Method and application of preparing oral powder of insulin through microcapsule technique

  • CN 1,660,416 A
  • Filed: 02/27/2004
  • Published: 08/31/2005
  • Est. Priority Date: 02/27/2004
  • Status: Active Application
First Claim
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1. , a kind ofly prepare the method for oral insulin dry powder, it is characterized in that this method finishes according to the following steps with food " microcapsule " technology:

  • ---weighing;

    will be with the synthetic insulin for preparing (each content all can) n, propolis alcoholic solution, glucose n1, by weight taking by weighing n part insulin respectively, 97-n-n1-x part f propolis, n1 part glucose, wherein n is any natural number of 1 to 30;

    ---the preparation (x) of forced for vitamins breast;

    be by weight respectively with vitamin e, vitamin c derivant;

    take by weighing at 1;

    1, join in the vegetable oil, vegetable oil and insulin weight ratio are 1;

    1;

    Adding monoglyceride again in vegetable oil, is 50% by the vegetable oil weight ratio, is heated to thawing, mix homogeneously.---drying;

    with propolis insulin ethanol mixed solution and forced for vitamins breast mix homogeneously, adopt spray drying method, inlet temperature is that 140 to spend to 180 degree, temperature of outgoing air be 30 to spend to 40 degree, makes dry powder.---finished product;

    generate the oral insulin dry powder that contains n%.

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