Composition, synthesis and therapeutic applications of polyamines

Composition, synthesis and therapeutic applications of polyamines

  • CN 1,688,298 A
  • Filed: 12/18/2002
  • Published: 10/26/2005
  • Est. Priority Date: 12/18/2001
  • Status: Active Application
First Claim
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1. method for the treatment of degenerative disease, described degenerative disease are because acquired mitochondrial DNA damage also damages the macromolecular oxygen of mitochondrion, and heritability mitochondrial gene defective causes, and described method comprises the steps:

  • (1) from following compounds, select synthetic;

    by 1, tetramine and polyamines that the straight chain that 3-propylene and/or vinyl group connect is dominant;

    By 1, tetramine and polyamines that the side chain that 3-propylene and/or vinyl group connect is dominant;

    By 1, the ring polyamines that 3-propylene and/or vinyl group connect;

    By one or more 1, the straight chain that 3-propylene and/or vinyl group connect, the combination of side chain and annular polyamines;

    The polyamines that replaces;

    Form the polyamines of tyrosine phosphatase inhibitors molecule to derive after the straight or branched connection, connect 2 with straight or branched, the polyamine derivative of 2-benzidine;

    (2) synthetic described synthetic;

    And(3) give the described synthetic of administration effective dose.

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