Adenovirus expressing genes in reverse order and use thereof

Adenovirus expressing genes in reverse order and use thereof

  • CN 1,705,740 B
  • Filed: 10/15/2003
  • Issued: 07/24/2013
  • Est. Priority Date: 10/15/2002
  • Status: Active Grant
First Claim
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1. recombinant adenovirus, it expressed first kind of albumen before expressing second kind of albumen, described first kind of albumen is selected from the albumen by E1B, the group that the proteic combination of E4 albumen and E1B albumen and E4 is formed, described second kind of albumen is E1A-albumen, wherein said first kind of proteic expression controlled by promotor, wherein said promotor is selected from by tumor-specific promoters, organ specific promoters, tissue-specific promoter, the group that allogeneic promoter and adenovirus promoter are formed, if be adenovirus promoter wherein about the proteic promotor of E1B, then described adenovirus promoter is different from the E1B promotor, if and be adenovirus promoter about the proteic promotor of E4, then described adenovirus promoter is different from the E4 promotor, and wherein the proteic expression of E1A is controlled by promotor, and wherein controlling the proteic expression promoter of E1A is YB-1 control.

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