A serum marker for measuring liver fibrosis

A serum marker for measuring liver fibrosis

  • CN 1,759,320 A
  • Filed: 01/14/2004
  • Published: 04/12/2006
  • Est. Priority Date: 01/14/2003
  • Status: Active Grant
First Claim
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1. ) a kind ofly detect the method that liver fibrosis in the mammal or liver fibrosis rank change, this method comprises:

  • A) produce the distribution plan of following material;

    the labeled derivative thing of carbohydrates or its derived fragment or described carbohydrates or described fragment or by the feature of determined described carbohydrates of the structure of described carbohydrates or described carbohydrates fragment or described carbohydrates fragment;

    Described carbohydrates or described fragment are present in the potpourri of glycoconjugate, or from be present in or separate the glycoconjugate potpourri from described mammalian body fluid sample, obtain andB) at least a carbohydrates or by the quantity of the labeled derivative thing of its derived fragment or described carbohydrates or described fragment in determination step distribution plan a), perhaps measure the feature be present at least a carbohydrates in the described carbohydrates distribution plan or its derived fragment andC) measurement data that obtains in the measurement data of gained in the step b) and the mammiferous distribution plan of not suffering from liver fibrosis is compared, in order to detect liver fibrosis, perhaps, gained data in the step b) are compared with the data of before measuring in described mammal, change in order to the rank that detects liver fibrosis, andD) carry out attribution to obtaining this comparative result in the step c), to detect mammiferous liver fibrosis or other variation of liver fibrosis level.

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