A serum marker for measuring liver fibrosis

A serum marker for measuring liver fibrosis

  • CN 1,759,320 B
  • Filed: 01/14/2004
  • Issued: 10/15/2014
  • Est. Priority Date: 01/14/2003
  • Status: Active Grant
First Claim
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1. the carbohydrates that at least one N-connects purposes in the carbohydrates distribution plan of the variation of liver fibrosis rank before liver fibrosis or cirrhosis before producing for detection of mammal cirrhosis, the carbohydrates that wherein said N-connects obtains from being present in or separating in the total reducing sugar protein mixture from described mammalian body fluid sample, and the carbohydrates that wherein said at least one N-connects is selected from:

  • I) glycan 1, it is GlcNAc (β

    -1,2) Man (α

    -1,3) [GlcNAc (β

    -1,2) Man (α

    -1,6)] Man (β

    -Isosorbide-5-Nitrae) GlcNAc (β

    -1,4) [Fuc (α

    -1,6)] GlcNAcIi) glycan 2, it is GlcNAc (β

    -1,2) Man (α

    -1,3) [GlcNAc (β

    -Isosorbide-5-Nitrae)] [GlcNAc (β

    -1,2) Man (α

    -1,6)] Man (β

    -Isosorbide-5-Nitrae) GlcNAc (β

    -Isosorbide-5-Nitrae) [Fuc (α

    -1,6)] GlcNAcIii) glycan 7, it is Gal (β

    -Isosorbide-5-Nitrae) GlcNAc (β

    -1,2) Man (α

    -1,3) [GlcNAc (β

    -Isosorbide-5-Nitrae)] [Gal (β

    -Isosorbide-5-Nitrae) GlcNAc (β

    -1,2) Man (α

    -1,6)] Man (β

    -Isosorbide-5-Nitrae) GlcNAc (β

    -Isosorbide-5-Nitrae) [Fuc (α

    -1,6)] GlcNAcIv) glycan 8, it is Gal (β

    -Isosorbide-5-Nitrae) GlcNAc (β

    -1,2) [Gal (β

    -1,4) GlcNAc (β

    -1,4)] Man (α

    -1,3) [Gal (β

    -Isosorbide-5-Nitrae) GlcNAc (β

    -1,2) Man (α

    -1,6)] Man (β

    -Isosorbide-5-Nitrae) GlcNAc (β

    -Isosorbide-5-Nitrae) GlcNAc.

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