Compounds for the treatment of metabolic disorders

Compounds for the treatment of metabolic disorders

  • CN 1,774,244 A
  • Filed: 04/08/2004
  • Published: 05/17/2006
  • Est. Priority Date: 04/15/2003
  • Status: Active Application
First Claim
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1. the purposes of a bioactivator in medication preparation, described medicine is used for the treatment of the morbid state that is selected from insulin resistance syndrome and comprises the diabetes of type i diabetes and type ii diabetes;

  • Or be used for the treatment of the following morbid state relevant with diabetes or be used to reduce the probability that develops into described morbid state of being correlated with diabetes, described morbid state is atherosclerosis, arteriosclerosis, obesity, hypertension, hyperlipemia, fatty liver disease, nephropathy, neuropathy, retinopathy, ulcer of foot or cataract;

    Or be used for the treatment of the morbid state that is selected from hyperlipemia, cachexia or obesity;

    Wherein, described activating agent is the chemical compound that is expressed from the next;

    Formula I WhereinN is 1 or 2;

    M is 0,1,2,3 or 4;

    Q is 0 or 1;

    T is 0 or 1;

    R 2It is alkyl with 1 to 3 carbon atom;

    R 3Be hydrogen, halogen, have the alkyl of 1 to 3 carbon atom or have the alkoxyl of 1 to 3 carbon atom;

    A is a phenyl, and this phenyl does not have substituent group or is selected from following 1 or 2 groups replacements;

    halogen, the alkyl with 1 or 2 carbon atom, perfluoro-methyl, the alkoxyl with 1 or 2 carbon atom and perfluor methoxyl group;

    PerhapsA is the cycloalkyl with 3 to 6 ring carbon atoms, and wherein, described cycloalkyl does not have substituent group or one of them or two ring carbon and replaced by methyl or ethyl list independently;

    PerhapsA is 5 yuan or 6 yuan of hetero-aromatic rings with 1 or 2 ring hetero atom that is selected from N, S and O, and this hetero-aromatic ring is by the remainder covalent bonding of ring carbon and formula I chemical compound;

    AndR 1Be hydrogen or the alkyl with 1 or 2 carbon atom, condition is when m is 0 or 1, R 1Not hydrogen;

    Perhaps, work as R 1When being hydrogen, this activating agent is the acceptable salt of the pharmacy of described chemical compound.

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