Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer

Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer

  • CN 1,780,611 B
  • Filed: 04/30/2004
  • Issued: 01/30/2013
  • Est. Priority Date: 04/30/2003
  • Status: Active Grant
First Claim
Patent Images

1. transdermal dosage form, it comprises:

  • The activating agent part, it comprises activating agent, and has proximal face and distal surface;

    AndThe inversion agent part, it comprises inversion agent, and is arranged in the distally of this activating agent part;

    It further comprises the interlayer between the distal surface that places activating agent part and inversion agent are partly, wherein this interlayer for the diffusion of activating agent and inversion agent for impermeable, and wherein this interlayer can be in the presence of the solvent that is selected from water, alcohol, ether and composition thereof at least part of dissolving and/or can allow the solvent infiltration that is selected from water, alcohol, ether and composition thereof;

    Wherein this activating agent partly defines at least one and extends to the passage of this distal surface from this proximal face.

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