For transmitting the signal of telecommunication to revise the apparatus and method of gene expression in heart tissue

For transmitting the signal of telecommunication to revise the apparatus and method of gene expression in heart tissue

  • CN 1,787,850 B
  • Filed: 03/10/2004
  • Issued: 12/16/2015
  • Est. Priority Date: 03/10/2003
  • Status: Active Grant
First Claim
Patent Images

1. be formulated a device for transmission signal, thus change the gene expression of myocyte in heart tissue in the mode changing the dirty function of Heart center, comprising:

  • At least one electrode, is suitable for applying electric field to live body heart tissue;

    Maker, be suitable for receiving the signal relevant with cardiomotility to determine that the parameter of the signal that will transmit and transmission one signal or signal group are at least one electrode described, wherein determine that this parameter makes the signal of described transmission directly affect and changes the gene expression dose in described heart tissue, the signal of wherein said transmission is cardiac contractility modulation CCM signal, it can cause the improvement of cell shown by mrna expression and muscle activity, and the mrna expression of multiple gene can be changed, thus improve cardiac functionWherein signal is transmitted one hour or the longer time, and wherein when not providing medicine to heart, described CCM signal has the ability of described change gene expression dose.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×