2-phenoxy- and 2-phenylsulfomamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders

2-phenoxy- and 2-phenylsulfomamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders

  • CN 1,802,159 B
  • Filed: 03/11/2004
  • Issued: 04/24/2013
  • Est. Priority Date: 03/24/2003
  • Status: Active Grant
First Claim
Patent Images

1. benzenesulfonamide derivatives or its salt,Wherein said salt is the upper acceptable salt of physiology, andDescribed benzenesulfonamide derivatives is selected from:

  • (R)-N-(1-aza-bicyclo [2.2.2] oct-3-yl)-5-cyano group-2-(3,5-, two chloro-phenoxy groups)-benzsulfamide;

    (S)-N-(1-aza-bicyclo [2.2.2] oct-3-yl)-5-cyano group-2-(3,5-, two chloro-phenoxy groups)-benzsulfamide;

    4-(3,5-, two chloro-phenoxy groups)-3-{4-[(2S)-(1-hydroxyl-1-methyl-ethyl)-pyrrolidin-1-yl]-piperidines-1-sulfonyl }-benzonitrile;

    4-(3,5-, two chloro-phenoxy groups)-3-[3-(2,5-dioxo-pyrrolidin-1-yl methyl)-4-pyrrolidin-1-yl-piperidines-1-sulfonyl]-benzonitrile;

    4-(3,5-, two chloro-phenoxy groups)-3-{4-[(2S)-methylol-pyrrolidin-1-yl]-piperidines-1-sulfonyl }-benzonitrile;

    4-(3,5-, two chloro-phenoxy groups)-3-{ (2S)-[(2S)-methylol-pyrrolidin-1-yl methyl]-pyrrolidine-1-sulfonyl }-benzonitrile;

    4-(3,5-, two chloro-phenoxy groups)-3-(4-((3S, 4S)-3,4-dihydroxy-pyrrolidin-1-yl)-piperidin-1-yl sulfonyl)-benzonitrile;

    (3 '"'"' S, 5 '"'"' S)-methyl isophthalic acid '"'"'-(5-cyano group-2-(3,5-, two chloro-phenoxy groups) benzenesulfonyl)-1,3 '"'"'-two pyrrolidines-5 '"'"'-carboxylate;

    3-(4-((3S, 4S)-3-(tert-butyl dimetylsilyl oxygen base)-4-hydroxyl pyrrolidine-1-yl) piperidin-1-yl sulfonyl)-4-(3,5-, two chloro-phenoxy groups)-benzonitrile;

    4-(3,5-, two chloro-phenoxy groups)-3-((3S, 3 '"'"' S, 4S)-3,4-dihydroxy-1,3 '"'"'-two pyrrolidines-1 '"'"'-Ji sulfonyl)-benzonitrile;

    (S)-1-(1-(5-cyano group-2-(3,5-, two chloro-phenoxy groups) benzenesulfonyl) piperidin-4-yl) pyrrolidine-2-carboxylic acid;

    4-(3,5-, two chloro-phenoxy groups)-3-(2-((3-hydroxyl pyrrolidine-1-yl) methyl) piperidin-1-yl sulfonyl)-benzonitrile;

    With(R)-5-cyano group-2-(3,5-, two chloro-phenoxy groups)-N-(2-(2,5-dioxo pyrrolidin-1-yl) ethyl)-N-(1-aza-bicyclo [2.2.2] oct-3-yl) benzsulfamide.

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