Production of pyriphenanthrenone as anti-fibrosis medicine

Production of pyriphenanthrenone as anti-fibrosis medicine

  • CN 1,817,862 A
  • Filed: 03/15/2006
  • Published: 08/16/2006
  • Est. Priority Date: 03/15/2006
  • Status: Active Application
First Claim
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1. the preparation method of a pyriphenanthrenone as anti-fibrosis medicine is characterized in that adopting 2-amino-5-picoline (structural formula II) to be initial feed, carries out diazotization in acidic medium, obtains 5-methyl-2 (1H) pyridone shown in the structural formula II I after the hydrolysis;

  • Resulting formula (III) is carried out nucleophilic substitution reaction with the halogenated benzene compound shown in the formula (IV) in the presence of catalyzer, generate target compound---pirfenidone (I), and purified pure product.

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