Injection type pH sepsitive chitin quarternary ammonium salt aquagel and its preparation method

Injection type pH sepsitive chitin quarternary ammonium salt aquagel and its preparation method

  • CN 1,830,420 B
  • Filed: 03/08/2005
  • Issued: 07/25/2012
  • Est. Priority Date: 03/08/2005
  • Status: Active Grant
First Claim
Patent Images

1. injection type pH sepsitive chitin quarternary ammonium salt aquagel;

  • Said chitin quarternary ammonium salt aquagel is lower than 30 ℃

    , pH in temperature and between 6.8-8.0, is solution;

    Between 6.8-8.0, form hydrogel at temperature 30-60 ℃

    , pH, it prepares through following method;

    (1) be 1 with mol ratio;

    2-1;

    10 chitosan and 2,3-epoxypropyl trimethylammonium chloride ammonium with acetone precipitation, washing, obtain the chitosan quaternary ammonium salt that the quaternary ammonium group substitution value is 20%-100% through oven dry after reaction a period of time between 60-90 ℃

    ;

    (2) chitosan quaternary ammonium salt described in the step (1) is dissolved in the chitosan quaternary ammonium saline solution that obtains 1.0-10.0wt% in the acid solution of pH2.0-6.0;

    (3) between 1-10 ℃

    , the phosphoglycerol saline solution of 1.0-20.0wt% is dropwise added in the chitosan quaternary ammonium saline solution described in the step (2), stir and obtain the even limpid mixed solution of pH between 6.5-8.0;

    (4) elevated temperature is to gelation temperature, and constant temperature a period of time, obtains the chitin quarternary ammonium salt aquagel of homogeneous transparent.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×