Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same

Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same

  • CN 1,833,034 A
  • Filed: 06/18/2004
  • Published: 09/13/2006
  • Est. Priority Date: 06/20/2003
  • Status: Active Grant
First Claim
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1. oligonucleotide probe library, each probe in its Chinese library is formed by recognition sequence label and test section, wherein, at least one monomer is the monomer analogue of modifying in each oligonucleotide probe, thereby for corresponding unmodified oligodeoxynucleotide, increased binding affinity to complementary target sequence, these library probes have the substantive part that enough stability can be used for the combination of sequence-specific ground and detect the target nucleic acid of any given target colony thus, and, wherein, the number of different recognition sequences account for have given length might sequence label less than 10%.

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