Antibodies specific for sclerostin and methods for increasing bone mineralization

Antibodies specific for sclerostin and methods for increasing bone mineralization

  • CN 1,835,974 A
  • Filed: 06/15/2004
  • Published: 09/20/2006
  • Est. Priority Date: 06/16/2003
  • Status: Active Application
First Claim
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1. with separation antibody or its Fab of SOST polypeptide specific combination, described SOST polypeptide comprises SEQ ID NO:

  • 1,20,58,60,62, or aminoacid sequence shown in 68, wherein said antibody competition inhibition SOST polypeptide and (i) Delicious peptide (BMP) I receptor binding site and (ii) combining of one at least in the BMP II receptor binding site, wherein BMP I receptor binding site can be selected from GenBank numbering NM_004329 (SEQ ID NO;

    71) with comprising, D89675 (SEQ ID NO;

    72), NM_001203 (SEQ ID NO;

    73), S75359 (SEQID NO;

    74), NM_030849 (SEQ ID NO;

    75), D38082 (SEQ ID NO;

    76), NP_001194 (SEQ ID NO;

    77), the BMP I receptor polypeptide combination of the aminoacid sequence shown in the sequence of BAA19765 (SEQ ID NO;

    78) and AAB33865 (SEQID NO;

    79), wherein BMP II receptor binding site can be selected from GenBank numbering U25110 (SEQ ID NO;

    80) with comprising, NM_033346 (SEQ ID NO;

    81), Z48923 (SEQ ID NO;

    83), CAA88759 (SEQ ID NO;

    84), and the BMP II receptor polypeptide combination of the aminoacid sequence shown in the sequence of NM_001204 (SEQ ID NO;

    82).

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