Solid pharmaceutical dosage form

Solid pharmaceutical dosage form

  • CN 1,901,884 B
  • Filed: 08/23/2004
  • Issued: 07/25/2012
  • Est. Priority Date: 08/28/2003
  • Status: Active Grant
First Claim
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1. solid pharmaceutical dosage formulation;

  • It comprises the solid dispersion of at least a hiv protease inhibitor at least a pharmaceutically acceptable water soluble polymer and at least a pharmaceutically acceptable surfactant;

    Wherein said hiv protease inhibitor is (2S;

    3S, 5S)-5-((N-(N-methyl-N-((2-isopropyl 4-thiazolyl) methyl) amino) carbonyl)-L-is valyl for N-) amino-2-(N-((5-thiazolyl) methoxyl group-carbonyl)-amino)-amino-1,6-diphenyl-3-hydroxyl hexane (ritonavir);

    And said pharmaceutically acceptable water soluble polymer has at least 50 ℃

    Tg;

    And the amount to account for formulation weight 50 to 85% exists, and wherein said pharmaceutically acceptable surfactant is the pharmaceutically acceptable non-ionic surface active agent with HLB value of 4 to 10, and pharmaceutically acceptable surfactant exists with the amount that accounts for formulation weight 2 to 20%.

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