Masked berberine hydrochloride micro pill and its prepn

Masked berberine hydrochloride micro pill and its prepn

  • CN 1,931,137 A
  • Filed: 09/19/2006
  • Published: 03/21/2007
  • Est. Priority Date: 09/19/2006
  • Status: Active Application
First Claim
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1. , masked berberine hydrochloride micro pill is made by the berberine hydrochloride micropill is coated;

  • It is characterized in that the berberine hydrochloride micropill here selects for use any one method of extruding in centrifugal granulation, centrifugal lamination method or the coating pan spheronization to make by berberine hydrochloride and pharmaceutic adjuvant;

    Used adjuvant is selected from any one or a few in microcrystalline Cellulose, starch, sucrose, the dextrin;

    By weight percentage, the consumption of adjuvant is 15~

    90% in the micropill;

    The used coating material of coating includes;

    filmogen, plasticizer, caking inhibiter;

    The filmogen here is selected from one or more in Eudragit E100, Eudragit E PO, Eudragit L100, the hydroxypropyl emthylcellulose;

    By weight percentage, the consumption of filmogen is 1~

    8% in the coated micropill;

    The plasticizer here is selected from Oleum Ricini, polyethylene glycol 6000, polyethylene glycol 1500, PEG400, any one or a few in dibutyl sebacate, the triethyl citrate;

    By weight percentage, plasticizer dosage is 5~

    8% of a filmogen in the coating material;

    The caking inhibiter here is selected from any one or a few in magnesium stearate, Pulvis Talci and the micropowder silica gel;

    By weight percentage, the consumption of caking inhibiter is 5~

    15% of a filmogen in the coating material;

    The particle diameter of preferred masked berberine hydrochloride micro pill is 100~

    600 μ

    m.

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