Tetrabenzyl voglibose crystallizing and preparing process

Tetrabenzyl voglibose crystallizing and preparing process

CN
  • CN 1,931,826 A
  • Filed: 07/17/2006
  • Published: 03/21/2007
  • Est. Priority Date: 07/17/2006
  • Status: Active Application
First Claim
Patent Images

1. , (1S) of crystallized form-(1 (hydroxyl), 2,4,5/1,3)-2,3,4-three-oxygen-benzyl-5-[(2-hydroxyl-1-(methylol) ethyl) amino]-1-carbon-benzyloxymethyl-1,2,3,4-hexanaphthene tetrol, its fusing point are at 89.7 ℃

  • ;

    And have a testing data of the X-ray diffraction peak value of following monocrystalline X-ray diffraction testing data, crystalline powder;

    (1). monocrystalline X-ray diffraction testing data;

    this crystal belongs to rhombic system, P2 (1) 2 (1) 2 (1) spacer, unit cell parameters is a=7.8487_, b=20.746_, c=20.988_, the R value is 0.0748;

    The space multistory structure of molecule as shown in Figure 2;

    Molecule at the structure cell accumulation graph of A direction as shown in Figure 3;

    Intermolecular by hydrogen bond action power in conjunction with as shown in Figure 4;

    Crystal data and structural modifications data;

    Molecular formula C 38H 45NO 7Molecular weight 627.75 Temperature 291(2)K Wavelength 0.71073_ Crystallographic system, spacerRhombic system, P2 (1) 2 (1) 2 (1)Unit cell parameters a=

    7.8487(16)_,

    α



    90°

    b=

    20.746(4)_,

    β



    90°

    c=

    20.988(4)_γ



    90°

    Volume 3417.4(12)_ 3Z, bulk density 4,

    1.220Mg/m 3Uptake factor 0.083mm -1 ?F(000) 1344 Crystalline size 0.20×

    0.18×

    0.18mm The θ

    scope of data gathering 1.38to?25.00deg. Indication range -9≤

    h≤

    9,

    -24≤

    k≤

    0,

    -24≤

    1≤

    24 The diffraction of collecting counts/and independently diffraction is counted 9647/3327[R(int)=

    0.0833 Integrity degree (Completeness to theta=25) 97.3%

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