Mutant receptors and they are based on the application in the inducible gene expression system of nuclear receptor

Mutant receptors and they are based on the application in the inducible gene expression system of nuclear receptor

  • CN 1,964,622 B
  • Filed: 05/02/2005
  • Issued: 08/26/2015
  • Est. Priority Date: 04/30/2004
  • Status: Active Grant
First Claim
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1. Gene expression and regulation system, comprises expression casette, and described expression casette can be expressed in host cell, and described expression casette comprises the polynucleotide of coded polypeptide, and described polypeptide comprises:

  • I) identify the DNA binding domains of response element, the gene that described response element is to be conditioned with its expression is connected;

    With, wherein there is one of following replacement mutation in 132 positions of SEQ ID NO;

    1;

    L132M, L132N, L132V or L132E in the H group nuclear receptor ligands binding domains ii) as shown in SEQ ID NO;

    1.

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