Multi-component medicine evaluation method

Multi-component medicine evaluation method

  • CN 1,965,233 B
  • Filed: 06/06/2005
  • Issued: 03/13/2013
  • Est. Priority Date: 06/07/2004
  • Status: Active Grant
First Claim
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1. the evaluation method of a multi-component medicine, this evaluation method is characterised in that, use at least as follows (1) is judged with the difference degree of a plurality of multi-component medicines of selecting as standard group the multi-component medicine as evaluation object to the resulting mahalanobis distance of step (5);

  • Wherein, described step is;

    Step (1);

    obtain described as the multi-component medicine of evaluation object and the finger-print data of the three dimension high efficiency liquid phase chromatography of other multi-component medicines of the same race that consist of standard group;

    Step (2);

    described finger-print data are compressed so that it is applicable to the MT method;

    Step (3);

    in the finger-print data of described step (2), distribute variable axle in the MT method with respect to the sequence number of multi-component medicine and elution time, perhaps with respect to the sequence number of multi-component medicine and detect wavelength and distribute variable axle in the MT method, and with signal intensity as the characteristic quantity in the MT method;

    Step (4);

    utilize the MT method, obtain unit space by the characteristic quantity of described step (3);

    Step (5);

    utilize the MT method, obtain the multi-component medicine mahalanobis distance that resulting unit space is started at from described step (4) as evaluation object.

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