Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases

Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases

  • CN 1,976,704 B
  • Filed: 05/24/2005
  • Issued: 12/05/2012
  • Est. Priority Date: 05/28/2004
  • Status: Active Grant
First Claim
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1. the purposes of substituted quinoline in the preparation medicine, wherein said medicine is used to treat drug resistance Mycobacterium strain infection, and said substituted quinoline is following chemical compound or its pharmaceutically acceptable acid or base addition salts,1-(6-bromo-2-methoxy yl-quinoline-3-yl)-4-dimethylamino-2-(3-fluoro-phenyl)-1-phenyl-Ding-2-alcohol;

  • 1-(6-bromo-2-methoxy yl-quinoline-3-yl)-4-dimethylamino-2-phenyl-1-phenyl-Ding-2-alcohol;

    1-(6-bromo-2-methoxy yl-quinoline-3-yl)-4-dimethylamino-2-naphthalene-1-base-1-phenyl-Ding-2-alcohol;

    Wherein said drug resistance Mycobacterium bacterial strain is selected from mycobacterium tuberculosis, mycobacterium smegmatis, Mycobacterium avium and Mycobacterium fortuitum strain.

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