Combined meningococcal conjugates with common carrier protein

Combined meningococcal conjugates with common carrier protein

  • CN 1,976,716 B
  • Filed: 04/29/2005
  • Issued: 07/09/2014
  • Est. Priority Date: 04/30/2004
  • Status: Active Grant
First Claim
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1. the preparation method with the compositions of the disease resisting Neisseria meningitidis and cause for immune patients, the method comprises the following steps:

  • (1) at least two kinds of the lower group of preparation;

    (a) capsular saccharides of (i) serum group A Neisseria meningitidis and (ii) conjugate of carrier protein;

    (b) (i) capsular saccharides of serum group C Neisseria meningitidis and (ii) conjugate of carrier protein;

    (c) (i) capsular saccharides of serum group W135 Neisseria meningitidis and (ii) conjugate of carrier protein;

    (d) (i) capsular saccharides of serum group Y Neisseria meningitidis and (ii) conjugate of carrier protein, wherein said conjugate (a), (b), (c) and at least two kinds of carrier proteins that employing is identical in (d), described identical carrier protein is common carrier;

    With(2) mix at least two kinds of conjugates preparing in (1),To produce the compositions of the common carrier that comprises not coupling form, the concentration of wherein said not coupling common carrier is less than 10 μ

    g/ml;

    (3) measure in compositions the not concentration of coupling common carrier;

    If (4-i) the concentration <

    10 μ

    g/ml of described not coupling carrier, accepts that said composition is made further production of vaccine and/or for giving people;

    If or (4-ii) coupling carrier concentration >

    10 μ

    g/ml not, refusal said composition.

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