Solid-forming local anesthetic formulations for pain control
First Claim
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1. A solid forming local anesthetic formulation, comprising:
- from about 4 wt % to about 10 wt % lidocaine,from about 4 wt % to about 10 wt % tetracaine,from about 10 wt % to about 18 wt % polyvinyl alcohol,from about 25.94 wt % to about 51.87 wt % water,from about 2 wt % to about 6 wt % of an emulsifying agent selected from sorbitan monopalmitate or sorbitan monostearate,from about 2 wt % to about 13 wt % petrolatum, andfrom about 18 wt % to about 36 wt % dicalcium phosphate,wherein the water to polyvinyl alcohol weight ratio (w/w) is greater than 2.4.
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Abstract
Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.
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Citations
19 Claims
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1. A solid forming local anesthetic formulation, comprising:
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from about 4 wt % to about 10 wt % lidocaine, from about 4 wt % to about 10 wt % tetracaine, from about 10 wt % to about 18 wt % polyvinyl alcohol, from about 25.94 wt % to about 51.87 wt % water, from about 2 wt % to about 6 wt % of an emulsifying agent selected from sorbitan monopalmitate or sorbitan monostearate, from about 2 wt % to about 13 wt % petrolatum, and from about 18 wt % to about 36 wt % dicalcium phosphate, wherein the water to polyvinyl alcohol weight ratio (w/w) is greater than 2.4. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 16, 17, 18)
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11. A solid forming local anesthetic formulation, comprising:
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from about 4 wt % to about 30 wt % of a eutectic mixture of lidocaine and tetracaine, from about 10 wt % to about 18 wt % polyvinyl alcohol, from about 25.94 wt % to about 51.87 wt % water, from about 2 wt % to about 13 wt % petrolatum, from about 2 wt % to about 6 wt % of an emulsifying agent selected from sorbitan monopalmitate or sorbitan monostearate, and from about 18 wt % to about 36 wt % dicalcium phosphate, wherein the water to polyvinyl alcohol weight ratio (w/w) is greater than 2.4. - View Dependent Claims (12, 13, 14, 19)
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Specification