Anti-sclerostin antibody, antigen binding fragment and medical use thereof
First Claim
Patent Images
1. An antibody or antigen-binding fragment thereof that specifically binds to human sclerostin, comprising:
- (I) a heavy chain variable region comprising a heavy chain complementarity determining region 1 (CDR1), a heavy chain CDR2, and a heavy chain CDR3 having the amino acid sequences of SEQ ID NO;
7, SEQ ID NO;
8, and SEQ ID NO;
9, respectively; and
a light chain variable region comprising a light chain CDR1, a light chain CDR2, and a light chain CDR3 having the amino acid sequences of SEQ ID NO;
10, SEQ ID NO;
11, and SEQ ID NO;
12, respectively;
or(II) a heavy chain variable region comprising a heavy chain CDR1, a heavy chain CDR2, and a heavy chain CDR3 having the amino acid sequences of SEQ ID NO;
7, SEQ ID NO;
13, and SEQ ID NO;
9, respectively; and
a light chain variable region comprising a light chain CDR1, a light chain CDR2, and a light chain CDR3 having the amino acid sequences of SEQ ID NO;
10, SEQ ID NO;
11, and SEQ ID NO;
12, respectively.
1 Assignment
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Accused Products
Abstract
Provided is a humanized antibody and chimeric antibody that specifically binds human sclerostin. The antibodies can be used for treating human bone metabolism related diseases such as osteoporosis (OP).
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Citations
20 Claims
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1. An antibody or antigen-binding fragment thereof that specifically binds to human sclerostin, comprising:
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(I) a heavy chain variable region comprising a heavy chain complementarity determining region 1 (CDR1), a heavy chain CDR2, and a heavy chain CDR3 having the amino acid sequences of SEQ ID NO;
7, SEQ ID NO;
8, and SEQ ID NO;
9, respectively; anda light chain variable region comprising a light chain CDR1, a light chain CDR2, and a light chain CDR3 having the amino acid sequences of SEQ ID NO;
10, SEQ ID NO;
11, and SEQ ID NO;
12, respectively;
or(II) a heavy chain variable region comprising a heavy chain CDR1, a heavy chain CDR2, and a heavy chain CDR3 having the amino acid sequences of SEQ ID NO;
7, SEQ ID NO;
13, and SEQ ID NO;
9, respectively; anda light chain variable region comprising a light chain CDR1, a light chain CDR2, and a light chain CDR3 having the amino acid sequences of SEQ ID NO;
10, SEQ ID NO;
11, and SEQ ID NO;
12, respectively. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification