Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
First Claim
Patent Images
1. A method of detecting inflammatory bowel disease in a subject, the method comprising:
- (a) obtaining a biological sample from the subject, wherein the biological sample is a serum sample;
(b) contacting the biological sample with a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs;
79-82;
(c) detecting an amount of an antibody in the biological sample that binds to the polypeptide; and
(d) comparing the amount of bound antibody to a predetermined cut-off value, wherein the presence of at least one type of inflammatory bowel disease is detected when the amount of bound antibody is higher than the cut-off value.
1 Assignment
0 Petitions
Accused Products
Abstract
Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn'"'"'s Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
14 Citations
13 Claims
-
1. A method of detecting inflammatory bowel disease in a subject, the method comprising:
-
(a) obtaining a biological sample from the subject, wherein the biological sample is a serum sample; (b) contacting the biological sample with a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs;
79-82;(c) detecting an amount of an antibody in the biological sample that binds to the polypeptide; and (d) comparing the amount of bound antibody to a predetermined cut-off value, wherein the presence of at least one type of inflammatory bowel disease is detected when the amount of bound antibody is higher than the cut-off value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
Specification