Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
First Claim
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1. An isolated nucleic acid comprising a genomic, complementary or composite polynucleotide sequence encoding a polypeptide having heparanase catalytic activity.
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Abstract
A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
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Citations
13 Claims
- 1. An isolated nucleic acid comprising a genomic, complementary or composite polynucleotide sequence encoding a polypeptide having heparanase catalytic activity.
- 8. A recombinant protein comprising a polypeptide having heparanase catalytic activity.
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13. A method of identifying a chromosome region harboring a heparanase gene in a chromosome spread comprising the steps of:
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(a) hybridizing the chromosome spread with a tagged polynucleotide probe encoding heparanase;
(b) washing the chromosome spread, thereby removing excess of non-hybridized probe; and
(c) searching for signals associated with said hybridized tagged polynucleotide probe, wherein detected signals being indicative of a chromosome region harboring a heparanase gene.
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Specification