Conformal coated microchip reservoir devices
First Claim
1. A microchip device for the controlled release or exposure of molecules or secondary devices comprising:
- a substrate having a plurality of reservoirs;
reservoir contents comprising molecules, a secondary device, or both, located in the reservoirs;
reservoir caps covering the reservoirs contents to isolate said contents from one or more environmental components outside the reservoirs, wherein the reservoir caps can be selectively disintegrated or permeabilized to expose the reservoir contents within selected reservoirs to said one or more environmental components; and
a conformal coating over the outer surface of at least a portion of the substrate other than the reservoir caps.
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Accused Products
Abstract
Microchip devices are provided with an inert and biocompatible conformal coating to mitigate adverse responses following device implantation in a patient, to contain and seal a drug or other material within the device, and/or to insulate the electrical connections to the device. The device can include: (1) a substrate having a plurality of reservoirs; (2) reservoir contents, such as a drug or biosensor, in the reservoirs; (3) reservoir caps covering the reservoirs to isolate the contents from environmental components outside the reservoirs; and (4) a conformal coating over the outer surface of at least a portion of the substrate other than the reservoir caps. The reservoir caps can be selectively disintegrated or permeabilized to expose the reservoir contents to environmental components. The conformal coating preferably comprises a vapor depositable polymeric material, such as parylene. Processes for controlling coating of the devices while facilitating reservoir cap exposure are provided.
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Citations
34 Claims
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1. A microchip device for the controlled release or exposure of molecules or secondary devices comprising:
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a substrate having a plurality of reservoirs;
reservoir contents comprising molecules, a secondary device, or both, located in the reservoirs;
reservoir caps covering the reservoirs contents to isolate said contents from one or more environmental components outside the reservoirs, wherein the reservoir caps can be selectively disintegrated or permeabilized to expose the reservoir contents within selected reservoirs to said one or more environmental components; and
a conformal coating over the outer surface of at least a portion of the substrate other than the reservoir caps. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 25, 26, 28, 29, 30, 31, 32, 33, 34)
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23. A method for sealing reservoirs containing molecules or devices in a microchip device, the method comprising:
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providing a substrate having a plurality of reservoirs, a front side, and a back side, the back side comprising a plurality of reservoir openings distal reservoir caps on the front side and in need of sealing;
loading reservoir contents comprising molecules, a secondary device, or both, into the reservoirs; and
applying a conformal coating barrier layer onto the reservoir contents over at least the reservoir openings to seal the reservoir openings.
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27. A method of applying a conformal coating to a microchip device comprising:
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vapor depositing a conformal coating material onto a microchip device which comprises a substrate having a front side, a back side, and at least two reservoirs containing molecules or devices for selective release or exposure, and reservoir caps positioned on the front side of the substrate on each reservoir over the molecules or devices, wherein release or exposure of the molecules or devices from the reservoir is controlled by diffusion through or disintegration of the reservoir cap; and
providing that the conformal coating does not coat or is removed from the reservoir caps.
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Specification