Anesthesia drug monitor

• US 20030156143A1
• Filed: 10/11/2002
• Published: 08/21/2003
• Est. Priority Date: 12/07/1999
• Status: Active Grant

• Current Assignee: University of Utah Research Foundation (State of Utah)
• Original Assignee: University of Utah (State of Utah)
• Inventors: Strayer, David, Albert, Robert, Syroid, Noah, Drews, Frank, Westenskow, Dwayne, Agutter, James
• Granted Patent: US 7,693,697 B2
• Time in Patent Office: Days
• US Class Current: 715/848
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: G06T 11/206 Drawing of charts or graphs
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

A method, system and apparatus for the monitoring, diagnosis and evaluation of the state of a dynamic drug display system is disclosed. This invention provides for the rapid cognitive grasp of the overall state of drug combination effects with respect to a dynamic system. The system provides for displayed objects, which change in real-time to show the changes of the functions of the system. In particular, this invention is directed to the processing and display of drug data for the use of doctors in the process of monitoring or administering drugs to patients.

Claims

1. A method for data representation, comprising:

(A) initializing variables;

(B) polling for data connection;

(C) decoding a header connected and polled;

(D) storing initialization data; and

(E) running a drug display routine.

2. A method for data representation, as recited in claim 1, wherein said initializing variables further comprises:

(1) setting the number of drugs to zero;

(2) initializing drug object pointer array;

(3) setting scene render flag to false;

(4) setting up the user window;

(5) creating plots; and

(6) calling a service routine if the process is idle.

3. A method for data representation, as recited in claim 1, wherein said run drug display step further comprises:

(1) starting a timer;

(2) polling from a data source;

(3) decoding a data packet; and

(4) setting a scene render flag to false.

4. A method for data representation, as recited in claim 2, wherein said decoding a data packet further comprises:

(a) testing for a header packet;

(b) testing for a message packet;

(c) testing for a data packet;

(d) decoding drug data if a data packet;

(e) testing if a new drug;

(f) creating a new drug record, if a new drug; and

(g) decoding drug data; and

predicting future of drug concentrations.

5. A method for data representation, as recited in claim 4, wherein said decoding drug data further comprises, decoding drug concentration and decoding drug infusion rate.

6. A system for data representation, comprising:

(A) a drug delivery system;

(B) a data stream device, in communication with said drug delivery system; and

(C) a drug display monitor, in communication with a data stream device.

7. A system for data representation, as recited in claim 6, wherein said drug delivery system further comprises:

(1) an infusion pump;

(2) an anesthetic administration machine; and

(3) one or more bar coded syringes.

8. A system for data representation, as recited in claim 6, wherein said drug delivery system further comprises a simulator, which simulates drug administration.

9. A system for data representation, as recited in claim 8, wherein said simulator simulates boles drugs.

10. A system for data representation, as recited in claim 8, wherein said simulator simulates infusion drugs.

11. A system for data representation, as recited in claim 8, wherein said simulator simulates anesthetic drugs.

12. A system for data representation, as recited in claim 8, wherein said simulator simulates sedative drugs.

13. A system for data representation, as recited in claim 8, wherein said simulator simulates analgesic drugs.

14. A system for data representation, as recited in claim 8, wherein said simulator simulates neuromuscular blocking agents.

15. A system for data representation, as recited in claim 6, wherein said drug display monitor, further comprises:

(1) a data decoder receiving data from said data stream device;

(2) a dosage calculator receiving decoded data from said data decoder;

(3) a drug modeler and normalizer receiving calculated data from said data decoder;

(4) a storage device, receiving drug and dosage data from said drug modeler and normalizer; and

(5) a display generator.

16. A system for data representation, as recited in claim 15, wherein said display generator produces a display of an effect of one or more drugs.

17. A system for data representation, as recited in claim 15, wherein said display generator produces a real-time display of:

(1) one or more present and past drug dosages and drug names;

(2) past, present and future plasma or effect site concentrations of a drug administered, displayed according to a frame of reference, which encompasses;

(A) the effect site concentration for sedatives at which a percentage of patients are unconscious;

(B) the effect site concentration for analgesics at which a percentage of patients would not exhibit pain from post-operative recovery of surgery; and

(C) the effect site concentration for neuromuscular blocking agents at which a percentage of patients would not exhibit a response from a train-of-four electrical muscle stimulation.

18. A system for data representation, as recited in claim 15, wherein said display generator produces a display of:

(1) one or more present and past drug dosages and drug names;

(2) past, present and future plasma or effect site concentrations of a drug administered, displayed according to a frame of reference, which encompasses;

(A) the effect site concentration for sedatives at which a percentage of patients are unconscious;

(B) the effect site concentration for analgesics at which a percentage of patients would not exhibit pain from post-operative recovery of surgery; and

(C) the effect site concentration for neuromuscular blocking agents at which a percentage of patients would not exhibit a response from a train-of-four electrical muscle stimulation.

29. A system for data representation, as recited in claim 17, further comprising a graph representing an additional effect, wherein said additional effect results from drug interactions, comprising:

(A) a system for executing a multi-dimensional pharmocodynamic mathematical model to simulate the interactive effects between sedatives and analgesics.

30. A system for data representation, as recited in claim 29, further comprising:

(1) information regarding receiving the potency of a drug;

(2) a calculator calculating the relative potency of a drug in a class of drugs; and

(3) a merge function combining the relative potencies of two or more drugs to calculate the total effect of said two or more drugs.

31. A system for data representation, as recited in claim 17, further comprising a graph representing an additional effect, wherein said additional effect results from drug interactions, comprising:

(A) a system for data representation that maps multi-dimensional drug effect surfaces, generated by a pharmocodynamic model, to the respective graph of the drug class with sedative and analgesia drug effect site concentrations as input.

32. A system for data representation, as recited in claim 31, further comprising:

(1) information relating the sedative and analgesic volumes of a drug;

(2) a calculator for calculating a combination effect of said drug with other drugs; and

(3) a correlator for mapping said combination effect to a two-dimensional graph.

33. A system for data representation, as recited in claim 17, further comprising a graph representing an additional effect, wherein said additional effect results from drug interactions, comprising:

(A) a system for differentiating the individual and interactive components for estimated drug effects in the data representation.

34. A system for data representation, as recited in claim 33, further comprising:

(1) a calculator for calculating an effect of a first drug acting alone;

(2) a display for displaying a first drug effect;

(3) a calculator for calculating an effect of a second drug acting alone;

(4) a display for displaying said second drug effect;

(5) a calculator for calculating a combined effect of said first and said second drug effects; and

(6) a display for displaying said combined effect.

19. A system for data representation, comprising:

(A) a processor, computing drug models, producing an internal representation of drug display data and decoding a data stream;

(B) a memory unit in communication with said processor;

(C) a long term memory unit in communication with said processor;

(D) a graphics adapter in communication with said processor; and

(E) a display monitor, in communication with said graphics adapter.

20. A system for data representation, as recited in claim 19, wherein said effect of said one or more drugs is represented in real time, comprising:

(A) a graph depicting the pharmocodynamic effect of sedatives, referenced according to a measure of consciousness;

(B) a graph depicting the pharmocodynamic effect of analgesics, referenced according to a measure of surgical stimuli and laryngoscopy; and

(C) a graph depicting the pharmocodynamic effect of neuromuscular blocking agents, referenced according to a measure of neuromuscular blocking.

21. A system for data representation, as recited in claim 19, wherein said effect of said one or more drugs is represented comprising:

(A) a graph depicting the pharmocodynamic effect of sedatives, referenced according to a measure of consciousness;

(B) a graph depicting the pharmocodynamic effect of analgesics, referenced according to a measure of surgical stimuli and laryngoscopy; and

(C) a graph depicting the pharmocodynamic effect of neuromuscular blocking agents, referenced according to a measure of neuromuscular blocking.

22. A system for data representation, as recited in claim 21, wherein said pharmocodynamic effect is a sedation effect.

23. A system for data representation, as recited in claim 21, wherein said pharmocodynamic effect is an analgesic effect.

24. A system for data representation, as recited in claim 21, wherein said pharmocodynamic effect is a neuromuscular effect.

25. A system for data representation, as recited in claim 21, wherein said measure of consciousness further comprises a reference indicator indicating a percentage of effectiveness of drug effect on a patient.

26. A system for data representation, as recited in claim 21, wherein said measure of surgical stimuli and laryngoscopy further comprises a reference indicator indicating a percentage of effectiveness of drug effect on a patient.

27. A system for data representation, as recited in claim 21, wherein said measure of neuromuscular blocking further comprises a reference indicator indicating a percentage of effectiveness of drug effect on a patient.

28. A system for data representation, as recited in claim 21, wherein said effect of said one or more drugs comprises sedation, analgesia, or neuromuscular blockade.