Methods of monitoring glucose levels in a subject and uses thereof
First Claim
1. A method for evaluating compliance with a weight management program in a subject, said method comprising determining a reference range of glucose amounts or concentrations that correspond to achieving a weight management goal in the subject, said range of glucose amounts or concentrations comprising a high threshold glucose value and a low threshold glucose value, monitoring glucose amount or concentration in the subject by a glucose monitoring method comprising transdermally extracting a sample comprising glucose from the subject using a sampling system that is in operative contact with a skin or mucosal surface of said subject, wherein the extracting is carried out using an iontophoretic system comprising first and second iontophoretic electrodes;
- contacting the sample with a sensor element in the presence of glucose oxidase that reacts with glucose to produce hydrogen peroxide;
detecting the hydrogen peroxide with the sensor element that reacts electrochemically with the hydrogen peroxide to produce a detectable signal, wherein said detectable signal is specifically related to glucose amount or concentration in the subject;
measuring the detectable signal;
correlating the signal measurement to an amount or concentration of glucose in the subject; and
repeating said glucose monitoring method to obtain a series of glucose amounts or concentrations, in the subject, at selected time intervals;
maintaining a record of caloric intake; and
comparing said series of glucose amounts or concentrations, said record, and said reference range to evaluate compliance with the reference range of glucose amounts or concentrations to achieve the weight management goal of the subject.
3 Assignments
0 Petitions
Accused Products
Abstract
Methods of frequently monitoring glucose amounts and/or concentrations in a subject who is at risk for hypoglycemia, hyperglycemia, and/or glucose level fluctuations that put the subject at risk are provided. Also provided are methods of monitoring the effects of one or more pharmaceutical compositions on the levels of glucose in a subject.
123 Citations
28 Claims
-
1. A method for evaluating compliance with a weight management program in a subject, said method comprising
determining a reference range of glucose amounts or concentrations that correspond to achieving a weight management goal in the subject, said range of glucose amounts or concentrations comprising a high threshold glucose value and a low threshold glucose value, monitoring glucose amount or concentration in the subject by a glucose monitoring method comprising transdermally extracting a sample comprising glucose from the subject using a sampling system that is in operative contact with a skin or mucosal surface of said subject, wherein the extracting is carried out using an iontophoretic system comprising first and second iontophoretic electrodes; -
contacting the sample with a sensor element in the presence of glucose oxidase that reacts with glucose to produce hydrogen peroxide;
detecting the hydrogen peroxide with the sensor element that reacts electrochemically with the hydrogen peroxide to produce a detectable signal, wherein said detectable signal is specifically related to glucose amount or concentration in the subject;
measuring the detectable signal;
correlating the signal measurement to an amount or concentration of glucose in the subject; and
repeating said glucose monitoring method to obtain a series of glucose amounts or concentrations, in the subject, at selected time intervals;
maintaining a record of caloric intake; and
comparing said series of glucose amounts or concentrations, said record, and said reference range to evaluate compliance with the reference range of glucose amounts or concentrations to achieve the weight management goal of the subject. - View Dependent Claims (2, 3, 4)
-
-
5. A method for monitoring an effect of at least one non-insulin-containing pharmaceutical composition on glucose levels in a subject receiving said pharmaceutical composition, the method comprising,
monitoring glucose amount or concentration in the subject by a glucose monitoring method comprising transdermally extracting a sample comprising glucose from the subject using a sampling system that is in operative contact with a skin or mucosal surface of said subject, wherein the extracting is carried out using an iontophoretic system comprising first and second iontophoretic electrodes; -
contacting the sample with a sensor element in the presence of glucose oxidase that reacts with glucose to produce hydrogen peroxide;
detecting the hydrogen peroxide with the sensor element that reacts electrochemically with the hydrogen peroxide to produce a detectable signal, wherein said detectable signal is specifically related to glucose amount or concentration in the subject;
measuring the detectable signal;
correlating the signal measurement to an amount or concentration of glucose in the subject; and
repeating said glucose monitoring method to obtain a series of glucose amounts or concentrations, in the subject, at selected time intervals;
maintaining a record of treatment with the pharmaceutical composition; and
comparing said series of glucose amounts or concentrations and said record to evaluate the effect of the pharmaceutical composition on glucose levels in the subject receiving said pharmaceutical composition. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12)
-
-
13. A method for improving prognosis and/or reduction of adverse side-effects associated with a disease state or condition in a subject, said method comprising
determining a reference range of glucose amounts or concentrations that correspond to achieving an improved prognosis or reduction of adverse side-effects associated with said disease state or condition in the subject, said range of glucose amounts or concentrations comprising a high threshold glucose value and a low threshold glucose value, monitoring glucose amount or concentration in the subject by a glucose monitoring method comprising transdermally extracting a sample comprising glucose from the subject using a sampling system that is in operative contact with a skin or mucosal surface of said subject, wherein the extracting is carried out using an iontophoretic system comprising first and second iontophoretic electrodes; -
contacting the sample with a sensor element in the presence of glucose oxidase that reacts with glucose to produce hydrogen peroxide;
detecting the hydrogen peroxide with the sensor element that reacts electrochemically with the hydrogen peroxide to produce a detectable signal, wherein said detectable signal is specifically related to glucose amount or concentration in the subject;
measuring the detectable signal;
correlating the signal measurement to an amount or concentration of glucose in the subject; and
repeating said glucose monitoring method to obtain a series of glucose amounts or concentrations, in the subject, at selected time intervals; and
comparing said series of glucose amounts or concentrations and said reference range to evaluate compliance with the reference range of glucose amounts or concentrations to achieve an improved prognosis or reduction of adverse side-effects associated with said disease state or condition in the subject, wherein said disease state or condition is not type I or type II diabetes. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
-
Specification