Device and method for determining analyte levels
First Claim
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1. An implantable device for measuring an analyte in a biological fluid, comprising;
- a) a housing comprising an electronic circuit; and
b) a sensor operably connected to said electronic circuit of said housing, said sensor comprising i) a member for determining the amount of glucose in a biological sample ii) a bioprotective membrane said bioprotective membrane positioned more distal to said housing than said glucose determining member and substantially impermeable to macrophages, and iii) an angiogenic layer, said angiogenic layer positioned more distal to said housing than said bioprotective membrane.
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Abstract
Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
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Citations
43 Claims
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1. An implantable device for measuring an analyte in a biological fluid, comprising;
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a) a housing comprising an electronic circuit; and
b) a sensor operably connected to said electronic circuit of said housing, said sensor comprising i) a member for determining the amount of glucose in a biological sample ii) a bioprotective membrane said bioprotective membrane positioned more distal to said housing than said glucose determining member and substantially impermeable to macrophages, and iii) an angiogenic layer, said angiogenic layer positioned more distal to said housing than said bioprotective membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 28, 29, 30, 31)
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24. A combination angiogenic/bioprotective membrane comprising ePTFE embedded in the surface of a biostable polymer comprising about 30% by weight of PVP and a biostable urethane.
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32. An implantable device for continuous glucose monitoring comprising:
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(a) a housing comprising an electronic circuit; and
(b) a sensor operably connected to said electronic circuit of said housing, said sensor comprising (i) a member for determining the amount of glucose in a biological sample and (ii) a bioprotective member positioned more distal to said housing than said glucose determining member and including a bioprotective membrane having a tissue interface and a sensor interface, said membrane being substantially impermeable to macrophages at its sensor interface and promoting vascularization at its tissue interface. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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Specification