Method and kit for the transderaml determinaton of analyte concentration in blood

• US 20040030228A1
• Filed: 07/25/2003
• Published: 02/12/2004
• Est. Priority Date: 09/29/2000
• Status: Active Grant

• Current Assignee: Falk Fish
• Original Assignee: Falk Fish
• Inventors: Fish, Falk
• Granted Patent: US 7,004,901 B2
• Time in Patent Office: Days
• US Class Current: 600/309
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

A method is provided for determining the level of an analyte in the blood of an individual by measuring the level of the analyte in an interstitial fluid or in any other non blood fluid which does not contain red blood cells and adjusting the measurement value by the concentration of at least one reference analyte.

Claims

1. A method for determining the level of an analyte in the blood of an individual by measuring the level of said analyte in an interstitial fluid or in any other non blood fluid which does not contain red blood cells and adjusting the measurement value by the concentration of at least one reference analyte.

2. A method according to claim 1, wherein no skin permeation enhancers are used.

3. A method according to claim 1, wherein said analyte is glucose.

4. A method according to claim 1, wherein said at least one reference analyte is an electrolyte.

5. A method according to claim 4, wherein said electrolyte is a calcium ion.

6. A method for determining the level of an analyte in the blood of an individual comprising:

(i) contacting the skin of said individual with water to obtain a water specimen;

(ii) determining the level of said analyte in said water specimen;

(iii) determining the level of one or more reference analytes in the water specimen;

(iv) calculating the level of said analyte in the blood of the tested individual based on the measurements in (ii) and (iii).

7. A method according to claim 6, wherein said water contacted with the skin of said individual contains no skin permeation enhancers.

8. A method according to claim 6, wherein said analyte is glucose.

9. A method according to claim 6, wherein said at least one reference analyte is an electrolyte.

10. A method according to claim 9, wherein said electrolyte is a calcium ion.

11. A kit for determining the level of an analyte in the blood of a tested individual comprising:

(i) A collecting member obtaining a water specimen from skin of said individual;

(ii) a measurer measuring the level of the tested analyte in the obtained sample;

(iii) a measurer measuring the level of a reference analyte in the sample;

said collecting member may be a container in which the water is collected directly from the individual'"'"'s skin or a solid surface from which the water is collected into a container.

12. A kit according to claim 11, further comprising a calculator calculating the level of said tested analyte in the blood of the tested individual on the basis of the measurements obtained in (ii) and (iii) above.

13. A kit according to claim 11, further comprising a test strip incorporating the reagents or structures necessary to carry out the measurement of the tested analyte and reference analyte.

14. A kit according to claim 11, wherein said collecting member is also said measurer.