Devices for intrabody delivery of molecules and systems and methods utilizing same
First Claim
1. A device for controlled release of molecules comprising:
- (a) a device body having at least one reservoir therein for containing the molecules, said at least one reservoir being formed with a barrier impermeable to the molecules thereby preventing release thereof from said at least one reservoir; and
(b) at least one acoustic transducer being attached to, or forming a part of, said device body, said at least one acoustic transducer being for converting an acoustic signal received thereby into an electrical signal, said electrical signal leading to barrier permeabilization and therefore release of the molecules from said at least one reservoir.
0 Assignments
0 Petitions
Accused Products
Abstract
A device for controlled release of molecules is provided. The device including: (a) a device body having at least one reservoir therein for containing the molecules, the at least one reservoir being formed with a barrier impermeable to the molecules thereby preventing release thereof from the at least one reservoir; and (b) at least one acoustic transducer being attached to, or forming a part of, the device body, the at least one acoustic transducer being for converting an acoustic signal received thereby into an electrical signal, the electrical signal leading to barrier permeabilization and therefore release of the molecules from the at least one reservoir.
-
Citations
43 Claims
-
1. A device for controlled release of molecules comprising:
-
(a) a device body having at least one reservoir therein for containing the molecules, said at least one reservoir being formed with a barrier impermeable to the molecules thereby preventing release thereof from said at least one reservoir; and
(b) at least one acoustic transducer being attached to, or forming a part of, said device body, said at least one acoustic transducer being for converting an acoustic signal received thereby into an electrical signal, said electrical signal leading to barrier permeabilization and therefore release of the molecules from said at least one reservoir. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
-
-
16. A device for controlled drug release comprising:
-
(a) a device body including at least one reservoir being for containing a prodrug form of a drug, said at least one reservoir being formed with a barrier impermeable to said prodrug thereby preventing release thereof from said at least one reservoir; and
(b) at least one acoustic transducer being attached to, or forming a part of said device body, said at least one acoustic transducer being for converting an acoustic signal received thereby into an electrical signal, said electrical signal leading to a conversion of said prodrug into said drug, said drug being capable of traversing said barrier thereby releasing from said at least one reservoir. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
-
-
29. A method of delivering molecules to a specific body region, the method comprising:
-
(a) implanting within the body region a device including;
(i) a device body having at least one reservoir therein containing the molecules, said at least one reservoir being formed with a barrier impermeable to the molecules thereby preventing release thereof from said at least one reservoir; and
(ii) at least one acoustic transducer being attached to, or forming a part of, said device body, said at least one acoustic transducer being for converting an acoustic signal received thereby into an electrical signal, said electrical signal leading to barrier permeabilization and therefore release of the molecules from said at least one reservoir; and
(b) extracorporeally irradiating the body with an acoustic signal thereby causing the subsequent release of the molecules from said at least one reservoir. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37)
-
-
38. A system for localized delivery of molecules within the body comprising:
-
(a) an intrabody implantable device including;
(i) a device body having at least one reservoir therein for containing the molecules, said at least one reservoir being formed with a barrier impermeable to the molecules thereby preventing release thereof from said at least one reservoir; and
(ii) at least one acoustic transducer being attached to, or forming a part of, said device body, said at least one acoustic transducer being for converting an acoustic signal received thereby into an electrical signal, said electrical signal leading to barrier permeabilization and therefore release of the molecules from said at least one reservoir; and
(b) an extracorporeal unit for generating said acoustic signal.
-
-
39. A system for localized delivery of molecules within the body comprising:
-
(a) an intrabody implantable device including;
(i) a device body including at least one reservoir being for containing a prodrug form of a drug, said at least one reservoir being formed with a barrier impermeable to said prodrug thereby preventing release thereof from said at least one reservoir; and
(ii) at least one acoustic transducer being attached to, or forming a part of said device body, said at least one acoustic transducer being for converting an acoustic signal received thereby into an electrical signal, said electrical signal leading to a conversion of said prodrug into said drug, said drug being capable of traversing said barrier thereby releasing from said at least one reservoir; and
(b) an extracorporeal unit for generating said acoustic signal.
-
-
40. A method of fabricating a device for controllable release of molecules, the method comprising:
-
(a) providing a substrate;
(b) configuring said substrate with at least one reservoir;
(c) capping said at least one reservoir with a cap material which acts as an impermeable barrier to the molecules, said material becoming permeable to the molecules following generation of an electrical potential in or around said at least one reservoir; and
(d) providing an inlet port for filling said at least on reservoir with the molecules, said inlet being sealable following said filling, thereby generating the device for controllable release of molecules. - View Dependent Claims (41, 42, 43)
-
Specification