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Compositions comprising alternating 2'-modified nucleosides for use in gene modulation

  • US 20050026160A1
  • Filed: 11/04/2003
  • Published: 02/03/2005
  • Est. Priority Date: 11/05/2002
  • Status: Active Grant
First Claim
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34. A composition comprising a first oligomeric compound and a second oligomeric compound, wherein:

  • at least a portion of said first oligomeric compound is capable of hybridizing with at least a portion of said second oligomeric compound;

    at least a portion of said first oligomeric compound is complementary to and capable of hybridizing to a selected nucleic acid target;

    at least one of said first and said second oligomeric compounds comprises at least nucleosides of a first type (F) and nucleosides of a second type (S);

    said first and said second types of nucleosides differing in at least one aspect from one another in that they have different 2′

    -substituent groups; and

    when said 2′

    -substituent groups of said first and said second types of nucleosides are other than H or OH then at least one of said first and said second oligomeric compounds includes at least two nucleosides of said first type and at least one nucleoside of said second type wherein said nucleosides of said first type and said nucleosides of said second type are located with respect to one another such that said first or second oligomeric compound includes at least one FSF motif;

    or when the 2′

    -substituent group of one of said first or said second type of nucleoside is H or OH then at least one of said first and said second oligomeric compounds includes at least three nucleosides of said first type and at least three nucleosides of said second type and said nucleosides of said first type and said nucleosides of said second type are located with respect to one another such that at least one of said first and said second oligomeric compounds includes at least one FSFSFS motif.

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