Tissue implantable sensors for measurement of blood solutes
First Claim
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1. A device for estimating the concentration of an analyte in a biological environment, said device comprising:
- (a) a body;
(b) at least two primary detectors disposed on the body, wherein each primary detector is adapted to produce a signal responsive to the concentration of the analyte in the immediate biological microenvironment; and
, (c) signal processing means in communication with each individual primary detector for receiving a signal therefrom and estimating the concentration of the analyte in the biological environment from the signals said signal processing means employing one or more predetermined algorithms, said signal processing means comprising;
(i) means for adjusting the signals from each primary detector by applying signal adjustment coefficients thereto, wherein the coefficients compensate for detector failure, detector drift or variations between the biological microenvironments occupied by each detector;
(ii) means for estimating the analyte concentration in the biological microenvironment of individual primary detectors; and
(iii) means for estimating the concentration of the analyte by mathematical calculation of a primary composite signal indicative of said analyte concentration.
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Abstract
A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes a multiplicity of detectors, constructed and arranged to improve the probability that one or more detectors will have access to a vascular source at points in time sufficient to permit accurate measurements to be taken. Means and methods for calculating solute levels using the sensor device of the invention are also provided.
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Citations
57 Claims
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1. A device for estimating the concentration of an analyte in a biological environment, said device comprising:
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(a) a body;
(b) at least two primary detectors disposed on the body, wherein each primary detector is adapted to produce a signal responsive to the concentration of the analyte in the immediate biological microenvironment; and
,(c) signal processing means in communication with each individual primary detector for receiving a signal therefrom and estimating the concentration of the analyte in the biological environment from the signals said signal processing means employing one or more predetermined algorithms, said signal processing means comprising;
(i) means for adjusting the signals from each primary detector by applying signal adjustment coefficients thereto, wherein the coefficients compensate for detector failure, detector drift or variations between the biological microenvironments occupied by each detector;
(ii) means for estimating the analyte concentration in the biological microenvironment of individual primary detectors; and
(iii) means for estimating the concentration of the analyte by mathematical calculation of a primary composite signal indicative of said analyte concentration. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 52, 53, 54, 55)
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2. A device for estimating the concentration of an analyte in a biological environment, said device comprising:
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(a) a body;
(b) at least two primary detectors disposed on the body, wherein each primary detector is adapted to produce a signal responsive to the concentration of the analyte in the immediate biological microenvironment; and
,(c) signal processing means in communication with each individual primary detector for receiving a signal therefrom and estimating the concentration of the analyte in the biological environment from the signals said signal processing means employing one or more predetermined algorithms, said signal processing means comprising;
(i) means for estimating the analyte concentration in the biological microenvironment of individual primary detectors;
(ii) means for adjusting the analyte concentration estimates by applying signal adjustment coefficients thereto, wherein the coefficients compensate for detector failure, detector drift or variations between the biological microenvironments occupied by each detector; and
,(iii) means for estimating the concentration of the analyte by mathematical calculation of a primary composite signal indicative of said analyte concentration.
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29. A device for estimating the concentration of an analyte in a biological environment, said device comprising:
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(a) a body;
(b) at least one primary detector disposed on the body, wherein each primary detector is adapted to produce a signal responsive to the concentration of the analyte in the immediate biological microenvironment;
(c) a plurality of secondary detectors disposed on the body, wherein each secondary detector is adapted to produce a signal responsive to one or more confounding phenomena in the biological microenvironment of at least one primary detector; and
,(d) signal processing means in communication with each individual detector for receiving a signal therefrom, said signal processing means comprising;
(i) means for adjusting the signals from each secondary detector by applying signal adjustment coefficients thereto, wherein the coefficients compensate for detector failure, detector drift, variations between the biological microenvironments occupied by each detector, and confounding phenomena; and
,(ii) means for estimating the analyte concentration in the biological microenvironment of each individual primary detector; and
(iii) means for adjusting the estimated analyte concentration associated with each primary detector by applying signal adjustment coefficients thereto, wherein the coefficients compensate for detector failure, detector drift, variations between the biological microenvironments occupied by each detector, and confounding phenomena; and
(iv) means for estimating the concentration of the analyte by mathematical calculation of a primary composite signal indicative of said analyte concentration. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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56. A device for estimating the concentration of glucose in a biological environment, the device comprising an implantable detector array, wherein the detector array comprises:
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(a) a detector platform;
(b) at least one membrane containing immobilized glucose oxidase;
(b) a plurality of primary detectors disposed on the detector platform, wherein each primary detector is comprised of an oxygen sensor in communication with one such membrane; and
,(c) at least one secondary detector disposed on the platform, wherein each secondary detector is adapted to produce a signal responsive to oxygen in the biological microenvironment of the secondary detector.
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57. A device for estimating the concentration of glucose in a biological environment, the device comprising an implantable detector array, wherein the detector array comprises:
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(a) a detector platform;
(b) at least one membrane containing immobilized glucose oxidase;
(b) at least one primary detector disposed on the detector platform, wherein each primary detector is comprised of an oxygen sensor in communication with one such membrane; and
,(c) a plurality of secondary detectors disposed on the platform, wherein each secondary detector is adapted to produce a signal responsive to oxygen in the biological microenvironment of the secondary detector.
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Specification