Methods for modulating thermal and mechanical properties of coatings on implantable devices
First Claim
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1. A method of modulating thermal, mechanical, and surface properties of a coating on an implantable device, comprising:
- modulating a polymer having a low glass transition temperature (Tg) to generate a polymer having an increased Tg by a step selected from the group consisting of (a) altering the backbone of the polymer by reaction with a stiffening chemical agent;
(b) replacing the pendant groups of the polymer with less bulky linear groups or more bulky groups that increase potential rotation barrier of the polymer;
(c) increasing the molecular weight of the polymer;
(d) narrowing the molecular weight distribution of the polymer; and
(e) a combination of any of the processes as defined in (a)-(e), and forming a coating comprising the polymer having an increased Tg onto the implantable device.
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Abstract
Methods for modulating and enhancing thermal and mechanical properties and biocompatibilities of coatings on implantable devices are disclosed. Implantable devices containing the enhanced thermal and mechanical properties and biocompatibilities are also described. The implantable devices can be used to treat a medical condition such as vulnerable plaque or restenosis.
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Citations
59 Claims
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1. A method of modulating thermal, mechanical, and surface properties of a coating on an implantable device, comprising:
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modulating a polymer having a low glass transition temperature (Tg) to generate a polymer having an increased Tg by a step selected from the group consisting of (a) altering the backbone of the polymer by reaction with a stiffening chemical agent;
(b) replacing the pendant groups of the polymer with less bulky linear groups or more bulky groups that increase potential rotation barrier of the polymer;
(c) increasing the molecular weight of the polymer;
(d) narrowing the molecular weight distribution of the polymer; and
(e) a combination of any of the processes as defined in (a)-(e), and forming a coating comprising the polymer having an increased Tg onto the implantable device. - View Dependent Claims (6, 14, 19, 24, 32, 37, 42, 50, 55)
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2. A method of modulating thermal, mechanical, and surface properties of a coating on an implantable device, comprising:
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forming a polymer blend by blending a polymer having a low glass transition temperature (Tg) with a minor amount of a polymer having a high Tg or a semi-crystalline polymer having a melting temperature (Tm), and forming a coating comprising the polymer blend onto the implantable device. - View Dependent Claims (7, 15, 20, 25, 33, 38, 43, 51, 56)
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3. A method of modulating thermal, mechanical, and surface properties of a coating on an implantable device, comprising:
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modulating a polymer having a high glass transition temperature (Tg) to generate a polymer having an decreased Tg by a step selected from the group consisting of (a) replacing the pendant groups of the polymer with more bulky linear groups or less bulky groups that decrease potential rotation barrier of the polymer;
(b) decreasing the molecular weight of the polymer;
(c) broadening molecular weight distribution of the polymer; and
(d) a combination of any of the processes as defined in (a)-(c), and forming a coating comprising the polymer having an decreased Tg onto the implantable device. - View Dependent Claims (8, 16, 21, 26, 34, 39, 44, 52, 57)
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4. A method of modulating thermal, mechanical, and surface properties of a coating on an implantable device, comprising:
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forming a polymer blend by blending a polymer having a high glass transition temperature (Tg) with a minor amount of a polymer having a low Tg, and forming a coating comprising the polymer blend onto the implantable device. - View Dependent Claims (9, 17, 22, 27, 35, 40, 45, 53, 58)
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5. A method of modulating thermal, mechanical, and surface properties of a coating on an implantable device, comprising:
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forming a polymer blend by blending a polymer which is hydrophobic or comprises a hydrophobic component with a minor amount of a hydrophilic, non-fouling polymer, and forming a coating comprising the polymer blend onto the implantable device. - View Dependent Claims (10, 18, 23, 28, 36, 41, 46, 54, 59)
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11. A method of modulating thermal, mechanical, and surface properties of a coating on an implantable device, comprising
adding to the coating a material selected from the group consisting of chopped fibers, high surface/volume (S/V) ratio particulates, and the combination thereof, wherein the chopped fibers are selected from the group consisting of polyester fibers; - PLA fibers;
PHA fibers;
PLGA fibers;
PGA fibers;
polydioxanone (PDS) fibers;
absorbable glass fibers;
carbon nanotube fibers;
polyalkylene fibers;
polyethylene vinyl alcohol (EVAL) fibers;
polypropylene fibers; and
polyethylenetelephthalate (PET) fibers, andwherein the high surface/volume ratio particulates are selected from the group consisting of alumina particulates;
carbon nanoparticles;
carbon nanoshells;
carbon nanotubes;
hydroxyapatite;
tricalcium phosphate (TCP);
carbides;
nitrides;
TiO2;
SiO2;
calcium sulfate;
α
-tricalcium phosphate (TCP);
β
-tricalcium phosphate (TCP);
Carbonate-apatite (Dahlite);
titanium (Ti);
niobium (Nb);
tantalum (Ta);
platinum (Pt);
alloy of platinum and iridium (Ir) (Pt/Ir) and combination thereof. - View Dependent Claims (29, 47)
- PLA fibers;
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12. A method of modulating thermal, mechanical, and surface properties of a coating on an implantable device, comprising:
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forming a coating comprising a polymer having a low glass transition temperature (Tg) onto the implantable device, and modulating the coating to increase the Tg by a step selected from the group consisting of (a) altering the backbone of the polymer by reaction with a stiffening chemical agent;
(b) replacing the pendant groups of the polymer with less bulky linear groups or more bulky groups that increase potential rotation barrier of the polymer;
(c) increasing the molecular weight of the polymer; and
(d) a combination of any of the processes as defined in (a)-(c). - View Dependent Claims (30, 48)
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13. A method of modulating thermal, mechanical, and surface properties of a coating on an implantable device, comprising:
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forming a coating comprising a polymer having a high glass transition temperature (Tg) onto the implantable device, and modulating the coating to decrease the Tg by a step selected from the group consisting of (a) replacing the pendant groups of the polymer with more bulky linear groups or less bulky groups that decrease potential rotation barrier of the polymer;
(b) decreasing the molecular weight of the polymer;
(c) broadening molecular weight distribution of the polymer; and
(d) a combination of any of the processes as defined in (a)-(c). - View Dependent Claims (31, 49)
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Specification