Low oxygen in vivo analyte sensor
First Claim
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1. A wholly implantable analyte sensor system comprising:
- a wholly implantable body comprising an electrode configured to measure a glucose level in a host;
a membrane disposed over the electrode and configured to limit transport of glucose to the electrode;
a layer comprising an enzyme to catalyze a reaction of glucose and oxygen as a co-reactant; and
a sensor electronics unit operably connected to the electrode and configured to measure a current produced by the electrode, wherein the sensor electronics unit is configured to measure glucose concentration with substantial linearity at glucose concentrations of up to about 400 mg/dL at an oxygen concentration of less than about 0.6 mg/L.
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Abstract
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.
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Citations
28 Claims
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1. A wholly implantable analyte sensor system comprising:
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a wholly implantable body comprising an electrode configured to measure a glucose level in a host;
a membrane disposed over the electrode and configured to limit transport of glucose to the electrode;
a layer comprising an enzyme to catalyze a reaction of glucose and oxygen as a co-reactant; and
a sensor electronics unit operably connected to the electrode and configured to measure a current produced by the electrode, wherein the sensor electronics unit is configured to measure glucose concentration with substantial linearity at glucose concentrations of up to about 400 mg/dL at an oxygen concentration of less than about 0.6 mg/L. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A device for measuring a concentration of glucose in a biological fluid, the device comprising:
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a housing comprising an electronic circuit and at least one electrode operatively connected to the electronic circuit, wherein the electrode is configured to determine, in operation, a concentration of glucose in a biological sample; and
a glucose determining apparatus operatively connected to the electrode and comprising a membrane impregnated with an oxidase, wherein the electronic circuit is configured to measure, in operation, a current representative of the concentration of glucose in the biological sample, wherein the glucose determining apparatus is configured to measure glucose concentration with substantial linearity at glucose concentrations of up to about 400 mg/dL at an oxygen concentration of less than about 0.6 mg/L. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification