Analyte sensing biointerface

• US 20060257995A1
• Filed: 04/14/2006
• Published: 11/16/2006
• Est. Priority Date: 04/15/2005
• Status: Abandoned Application

• Current Assignee: James H. Brauker, Peter Simpson
• Original Assignee: James H. Brauker, Peter Simpson
• Inventors: Brauker, James H., Simpson, Peter
• Application Number:
  US11/404,421
• Publication Number:
  US 20060257995A1
• Time in Patent Office: Days
• US Class Current: 435/287.200
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

Claims

1. A sensor for measuring an analyte in a host, the sensor comprising a biointerface comprising a porous biocompatible matrix, wherein electroactive surfaces are distributed within at least some pores in the biointerface.

2. The sensor of claim 1, wherein the electroactive surfaces have a membrane coating disposed thereon.

3. The sensor of claim 1, wherein the porous biocompatible matrix is configured to support tissue ingrowth and comprises a plurality of interconnected cavities and a solid portion, and wherein a substantial number of the interconnected cavities are greater than or equal to about 20 microns in at least one dimension.

4. The sensor of claim 1, wherein the porous biocompatible matrix comprises a length of greater than one cavity in each of three dimensions substantially throughout the matrix.

5. The sensor of claim 1, wherein the cavities and a plurality of cavity interconnections are formed in a plurality of layers, wherein each layer has different cavity dimensions.

6. The sensor of claim 1, wherein the porous biocompatible matrix is configured to promote vascularization and interfere with barrier cell layer formation within the matrix, whereby the biocompatible matrix is suitable for long-term analyte transport in vivo.

7. The sensor of claim 1, wherein the porous biocompatible matrix comprises a plurality of fibers.

8. The sensor of claim 7, wherein the fibers have a size of between about 1 micron and about 100 microns in at least one dimension.

9. The sensor of claim 7, wherein the plurality of fibers are selected from the group consisting of woven fibers and non-woven fibers.

10. The sensor of claim 7, wherein at least one of the plurality of fibers comprise an electrode core.

11. The sensor of claim 10, wherein the fibers comprising an electrode core comprise a membrane surrounding the electrode core.

12. The sensor of claim 1, wherein the electroactive surfaces comprise an electroactive surface of at least one working electrode.

13. The sensor of claim 12, wherein the electroactive surfaces further comprise an electroactive surface of at least one reference electrode.

14. The sensor of claim 1, further comprising sensor electronics operably connected to the electroactive surfaces.

15. The sensor of claim 1, wherein the sensor is configured to measure glucose.

16. The sensor of claim 1, wherein pores within the porous biocompatible matrix have a size of between about 20 microns and about 1000 microns in at least one dimension.

17. The sensor of claim 1, wherein the porous biocompatible matrix comprises a bioactive agent.

18. An implantable analyte sensor, comprising:

a porous biocompatible matrix; and

electroactive surfaces incorporated into the biocompatible matrix in such a way so that the electroactive surfaces and biocompatible matrix manage a foreign body response to resist barrier cell formation and allow transport of analytes to the electroactive surfaces when the sensor is implanted into a body.