CLOSED LOOP NEURAL STIMULATION SYNCHRONIZED TO CARDIAC CYCLES
First Claim
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1. A system, comprising:
- a reference event detection circuit adapted to receive an input from a reference signal sensor and generate a synchronization control signal using a detected cardiac activity event;
a feedback detection circuit adapted to receive an input from a feedback sensor and generate a feedback control signal;
a stimulation control circuit adapted to generate a stimulation control signal, the stimulation control circuit including a synchronization circuit responsive to the synchronization control signal to time the stimulation control signal, the stimulation control circuit further including a therapy titration circuit responsive to the feedback control signal to adjust the stimulation control signal; and
a stimulation output circuit responsive to the stimulation control signal from the stimulation control circuit and adapted to generate a neural stimulation signal for use in stimulating at least one autonomic neural target.
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Abstract
Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
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Citations
48 Claims
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1. A system, comprising:
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a reference event detection circuit adapted to receive an input from a reference signal sensor and generate a synchronization control signal using a detected cardiac activity event; a feedback detection circuit adapted to receive an input from a feedback sensor and generate a feedback control signal; a stimulation control circuit adapted to generate a stimulation control signal, the stimulation control circuit including a synchronization circuit responsive to the synchronization control signal to time the stimulation control signal, the stimulation control circuit further including a therapy titration circuit responsive to the feedback control signal to adjust the stimulation control signal; and a stimulation output circuit responsive to the stimulation control signal from the stimulation control circuit and adapted to generate a neural stimulation signal for use in stimulating at least one autonomic neural target. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A system, comprising:
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a heart rate detector adapted to generate a synchronization control signal using a detected heart rate; a feedback detection circuit adapted to receive an input from a cardiac data sensor and generate a feedback control signal using detected cardiac data; a stimulation control circuit adapted to generate a stimulation control signal, the stimulation control circuit including a synchronization circuit responsive to the synchronization control signal to time the stimulation control signal, the stimulation control circuit further including a therapy titration circuit responsive to the feedback control signal to adjust the stimulation control signal; and a stimulation output circuit responsive to the stimulation control signal from the stimulation control circuit and adapted to generate a neural stimulation signal for use in stimulating at least one autonomic neural target. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30)
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31. A system, comprising:
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means for detecting cardiac activity; means for synchronizing neural stimulation with a reference event in the detected cardiac activity; and means for titrating neural stimulation based on a detected response to the neural stimulation. - View Dependent Claims (32, 33, 34)
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35. A method, comprising:
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detecting cardiac activity; synchronizing neural stimulation with a reference event in the detected cardiac activity; and titrating neural stimulation based on a detected response to the neural stimulation. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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Specification