Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots
First Claim
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1. A composition comprising a fibrinolytic or anticoagulant drug biocompatibly coupled to a red blood cell carrier.
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Abstract
Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers.
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Citations
9 Claims
- 1. A composition comprising a fibrinolytic or anticoagulant drug biocompatibly coupled to a red blood cell carrier.
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2. A composition comprising biotinylated plasminogen activator or biotinylated receptor for plasminogen activator precursor cross-linked monovalently to a biotinylated red blood cell carrier via streptavidin.
- 3. A composition comprising biotinylated plasminogen activator or biotinylated receptor for plasminogen activator precursor conjugated with a biotinylated monoclonal antibody specific for red blood cells via streptavidin.
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5. A method for minimizing potential hazardous interactions of urokinase with endothelial cells and activating a precursor form of urokinase in blood comprising contacting said inactive urokinase in blood with a composition comprising a soluble form of urokinase receptor biocompatibly coupled to a red blood cell carrier.
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9. A method for increasing pulmonary uptake of tissue plasminogen activator which comprises crosslinking of biotinylated tissue plasminogen activator to a biotinylated red blood cell or a biotinylated monoclonal antibody specific for red blood cells via streptavidin and administering said crosslinked tissue plasminogen activator to an animal.
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