Electrical Muscle Controller
First Claim
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1. Apparatus for treatment of congestive heart failure, the apparatus comprising:
- (a) a signal generator adapted to apply an electric signal to a cardiac tissue a;
(b) a controller adapted to operate the signal generator;
wherein the electric signal increases a contractility of cardiac muscle.
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Abstract
A method of modifying the force of contraction of at least a portion of a heart chamber, including providing a subject having a heart, comprising at least a portion having an activation, and applying a non-excitatory electric field having a given duration, at a delay after the activation, to the portion, which causes the force of contraction to be increased by a least 5%.
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Citations
44 Claims
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1. Apparatus for treatment of congestive heart failure, the apparatus comprising:
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(a) a signal generator adapted to apply an electric signal to a cardiac tissue a;
(b) a controller adapted to operate the signal generator;
wherein the electric signal increases a contractility of cardiac muscle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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- 10. A method of treating congestive heart failure, the method comprising applying an electric signal to cardiac tissue to increase a contractility of cardiac muscle.
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11. A method of treating congestive heart failure, the method comprising applying an electric signal adapted to exert positive control to cardiac tissue.
- 15. Use of electric pulses as a treatment for congestive heart failure.
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21. Apparatus adapted for modifying cardiac activity, the apparatus comprising:
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(a) a signal generator adapted to apply a non-excitatory signal to a cardiac tissue according to a programmable control sequence;
(b) a controller adapted to operate the signal generator according to the control sequence;
wherein the control sequence specifies a first number of beats in which a first control logic is applied and a second number of beats in which a second control logic is applied. - View Dependent Claims (22, 23, 24, 25, 26)
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- 27. A method for modifying cardiac activity, the method comprising applying a non-excitatory signal with a defined control sequence for a finite amount of time to a cardiac tissue.
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31. A method of ameliorating a clinical severity of congestive heart failure, the method comprising:
applying a non-excitatory electric field to at least a portion of a heart, the electric field characterized by a magnitude, shape, duty cycle, phase, frequency and duration suitable to obtain an increase in stroke volume. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38)
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39. A method of cardiac modeling, the method comprising:
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(a) applying a non-excitatory electric field to at least a portion of a heart to change a distribution of muscle mass in the heart; and
(b) ceasing to apply the non excitatory electric field after a desired change in distribution of muscle mass is achieved.
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- 40. Use of a non excitatory electric field applied to at least a portion of a heart to produce an inotropic effect.
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42. A method of treating heart failure, the method comprising:
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(a) applying a non-excitatory electric inotropic therapy program to a subject;
(b) modifying the therapy program responsive to an assessment of at least one parameter. - View Dependent Claims (43)
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44. A method of controlling nervous signals in peripheral nerves, the method comprising:
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(a) selecting a nerve; and
(b) applying a non-excitatory electric field to the nerve to attenuate conduction of a signal therein.
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Specification