LOW OXYGEN IN VIVO ANALYTE SENSOR
First Claim
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1. A continuous glucose sensor system comprising:
- an implantable body comprising an electrode configured to measure a glucose level in a host;
a membrane disposed over the electrode, wherein the membrane comprises a resistance domain configured to limit transport of glucose to the electrode and an enzyme to catalyze a reaction of glucose and oxygen as a co-reactant; and
a sensor electronics unit operably connected to the electrode and configured to measure a current produced by the electrode with substantial linearity at glucose concentrations of up to about 400 mg/dL in a fluid with an oxygen concentration of less than about 0.6 mg/L.
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Abstract
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.
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Citations
15 Claims
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1. A continuous glucose sensor system comprising:
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an implantable body comprising an electrode configured to measure a glucose level in a host; a membrane disposed over the electrode, wherein the membrane comprises a resistance domain configured to limit transport of glucose to the electrode and an enzyme to catalyze a reaction of glucose and oxygen as a co-reactant; and a sensor electronics unit operably connected to the electrode and configured to measure a current produced by the electrode with substantial linearity at glucose concentrations of up to about 400 mg/dL in a fluid with an oxygen concentration of less than about 0.6 mg/L. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A continuous glucose sensor, comprising:
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a sensor configured for transcutaneous insertion through a skin of a host, wherein the sensor comprises an electrode configured to measure a glucose level in a host; sensor electronics configured to configured to measure a signal produced by the electrode and convert the signal to a digital value with a resolution of at least about 1 mg/dL glucose/digital value. - View Dependent Claims (13, 14)
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15. A continuous glucose sensor, comprising:
a sensor configured for transcutaneous insertion through a skin of a host, wherein the sensor comprises an electrode configured to measure a glucose level in a host;
a membrane disposed over the electrode, wherein the membrane comprises a resistance domain configured to limit transport of glucose to the electrode and an enzyme to catalyze a reaction of glucose and oxygen as a co-reactant, wherein the sensor is configured such that less than about 1 μ
g of enzyme is consumed over 7 days of continuous operation.
Specification